Start Submission Become a Reviewer

Reading: A secondary metabolite with in vitro radical scavenging activity from endolichenic fungus Da...

Download

A- A+
Alt. Display

Research Articles

A secondary metabolite with in vitro radical scavenging activity from endolichenic fungus Daldinia eschscholzii found in lichen, Parmotrema sp. in Sri Lanka

Authors:

MATP Manthrirathna,

College of Chemical Sciences, Institute of Chemistry Ceylon, Adamantane House, 341/22, Kotte Road, Rajagiriya., LK
X close

R Kandiah,

College of Chemical Sciences, Institute of Chemistry Ceylon, Adamantane House, 341/22, Kotte Road, Rajagiriya., LK
X close

DS Gunasekera,

Sri Lanka Institute of Nanotechnology, Nanotechnology & Science Park, Mahenwatte, Pitipana, Homagama, LK
X close

KAU Samanthi,

Sri Lanka Institute of Nanotechnology, Nanotechnology & Science Park, Mahenwatte, Pitipana, Homagama, LK
X close

DT Welideniya,

Sri Lanka Institute of Nanotechnology, Nanotechnology & Science Park, Mahenwatte, Pitipana, Homagama, LK
X close

HAK Maduranga,

Faculty of Science, University of Kelaniya, Kelaniya, LK
About HAK
Department of Chemistry
X close

PA Paranagama

Faculty of Science, University of Kelaniya, Kelaniya, LK
About PA
Department of Chemistry
X close

Abstract

Endolichenic fungi, an unexplored group of microorganisms, are a promising source of bioactive compounds. Secondary metabolites were isolated from the chloroform fraction of crude ethyl acetate extract of endolichenic fungus Daldinia eschscholzii inhabiting the lichen, Parmotrema sp. in Sri Lanka. Two pure compounds, 1 and 2 were isolated and the structures were identified using 1H-, 13C-, 2D- nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) data. Compound 1 did not show any radical scavenging activity in DPPH assay. Compound 2, identified as 8-methoxynaphthalen-1-ol showed strong radical scavenging ability in the DPPH assay with a half maximal inhibitory concentration (IC50) of 10.2 ± 5.8 µg/ mL. The activity of compound 2 was higher than that of the standard, butylated hydroxy toluene (BHT).

 

 

 

How to Cite: Manthrirathna, M., Kandiah, R., Gunasekera, D., Samanthi, K., Welideniya, D., Maduranga, H. and Paranagama, P., 2020. A secondary metabolite with in vitro radical scavenging activity from endolichenic fungus Daldinia eschscholzii found in lichen, Parmotrema sp. in Sri Lanka. Journal of the National Science Foundation of Sri Lanka, 48(2).
Published on 30 Jun 2020.
Peer Reviewed

Downloads

comments powered by Disqus