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M-polynomial and topological indices for the anti-tuberculosis drugs

Authors:

TP Jude,

Eastern Uiversity, Sri Lanka, LK
About TP
Department of Mathematics, Faculty of Science
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P Elango ,

Eastern University, Sri Lanka, LK
About P
Department of Mathematics, Faculty of Science
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M Koneswaran

Eastern University, Sri Lanka, LK
About M
Department of Chemistry, Faculty of Science
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Abstract

Tuberculosis (TB) is one of the deadliest infectious diseases which is caused by the Mycobacterium tuberculosis. A group of first line anti-TB drugs namely isoniazid, rifampicin, pyrazinamide and ethambutol have been accepted for the treatment of drug susceptible tuberculosis. A topological index is a molecular structure descriptor which is a numerical value associated with chemical constitution for correlation of a chemical structure with its properties. The aim of this work is to investigate some degree-based topological indices for the above-mentioned anti-TB drugs using a polynomial approach. The molecular graphs of these anti-TB drugs structures were used to derive the M-Polynomials and then the derived formulas were used to calculate topological indices of the respective structures. This research could facilitate the design of new medicines against these pathogenic bacteria.

How to Cite: Jude, T., Elango, P. and Koneswaran, M., 2022. M-polynomial and topological indices for the anti-tuberculosis drugs. Journal of the National Science Foundation of Sri Lanka, 50(4), pp.827–838. DOI: http://doi.org/10.4038/jnsfsr.v50i4.10786
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Published on 31 Dec 2022.
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