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Comparison of radioactive iodine therapy outcome and the duration of pretreatment discontinuation of carbimazole among hyperthyroid patients: a prospective study

Authors:

S. Raheem ,

Faculty of Health-Care Sciences, Eastern University, Sri Lanka, LK
About S.
Department of Clinical Sciences
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D.K.K. Nanayakkara

Faculty of Medicine, University of Peradeniya, LK
About D.K.K.
Nuclear Medicine Unit
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Abstract

The outcome of radioactive iodine (131I) treatment among hyperthyroid patients can be affected by pretreatment with antithyroid drugs (ATD) and they should be discontinued before 131I treatment. This study aims to compare the outcome of 131I treatment among hyperthyroid patients who were off carbimazole for 3‒7 days and 8‒30 days before the 131I treatment. This prospective cohort study was carried out among 89 hyperthyroid patients referred for 131I treatment at the Nuclear Medicine Unit, Peradeniya (NMU) during August 2018 to February 2020. All these patients received a fixed activity of 10 mCi 131I. Each patient was followed up at a three-month interval for 06 months. The data were collected by directly interviewing the patients, from the clinical records and from the NMU database. Six months after 131I treatment among Graves’ disease (GD) patients, 17.9 % had euthyroidism, 59.7 % had hypothyroidism and 22.4 % had hyperthyroidism. The therapeutic success was 77.6 % among them. Of the Toxic Multi Nodular Goitre (TMNG) patients, 36.4 % had euthyroidism, 31.8 % had hypothyroidism and 31.8 % had hyperthyroidism. The overall therapeutic success was 68.2 % among them. Carbimazole discontinuation for 3‒7 days and 8‒30 days did not show a statistical difference with the 131I treatment outcomes in both GD (Chi-square value = 0.264, p value = 0.876) and TMNG (Chi-square value = 1.743, p value = 0.418). The minimum carbimazole off days among GD was 5 days and 3 days for the TMNG patients. Withholding carbimazole for more than 7 days (8‒30 days) before 131I treatment did not influence the therapeutic outcome and discontinuation of carbimazole can be decided on individual basis depending on the comorbid conditions.

How to Cite: Raheem, S. and Nanayakkara, D.K.K., 2022. Comparison of radioactive iodine therapy outcome and the duration of pretreatment discontinuation of carbimazole among hyperthyroid patients: a prospective study. Journal of the National Science Foundation of Sri Lanka, 50(2), pp.417–423. DOI: http://doi.org/10.4038/jnsfsr.v50i2.10477
Published on 09 Sep 2022.
Peer Reviewed

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