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Research Articles

The anti-genotoxic effect of some lichenic acids

Authors:

Hamit Emre Kizil,

Bayburt University, TR
About Hamit
Vocational School of Health Services
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Selcuk Ceker ,

Agri Ibrahim Cecen University, TR
About Selcuk
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy
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Ozel Capik,

Ataturk University, TR
About Ozel
Department of Biology, Faculty of Science
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Guleray Agar

Ataturk University, TR
About Guleray
Department of Biology, Faculty of Science
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Abstract

Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 μgmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 μgmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.

How to Cite: Kizil, H.E., Ceker, S., Capik, O. and Agar, G., 2018. The anti-genotoxic effect of some lichenic acids. Journal of the National Science Foundation of Sri Lanka, 46(2), pp.227–231. DOI: http://doi.org/10.4038/jnsfsr.v46i2.8423
Published on 30 Jun 2018.
Peer Reviewed

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