Research Articles
The anti-genotoxic effect of some lichenic acids
Authors:
Hamit Emre Kizil,
Bayburt University, TR
About Hamit
Vocational School of Health Services
Selcuk Ceker ,
Agri Ibrahim Cecen University, TR
About Selcuk
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy
Ozel Capik,
Ataturk University, TR
About Ozel
Department of Biology, Faculty of Science
Guleray Agar
Ataturk University, TR
About Guleray
Department of Biology, Faculty of Science
Abstract
Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 μgmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 μgmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.
How to Cite:
Kizil, H.E., Ceker, S., Capik, O. and Agar, G., 2018. The anti-genotoxic effect of some lichenic acids. Journal of the National Science Foundation of Sri Lanka, 46(2), pp.227–231. DOI: http://doi.org/10.4038/jnsfsr.v46i2.8423
Published on
30 Jun 2018.
Peer Reviewed
Downloads
