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Two new antioxidant active polyketides from Penicillium citrinum, an endolichenic fungus isolated from Parmotreama species in Sri Lanka

Authors:

KAU Samanthi,

LK
About KAU
Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya.
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S Wickramaarachchi,

LK
About S
Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya.
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EMK Wijeratne,

US
About EMK
Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.
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PA Paranagama

LK
About PA
Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya.
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Abstract

Bioassay guided fractionation of the ethyl acetate extract of a laboratory culture of Penicillium citrinum, an endolichenic fungal strain isolated from a Parmotrema species in Sri Lanka, led to the isolation of two new fungal polyketides (1 and 2). The structures of these compounds were determined on the basis of their 1D NMR, 2D NMR and FABMS spectroscopic data. The two compounds (1 and 2) showed radical scavenging activity with IC50 values of 159.7 ± 22.3 μg/mL and 68.6 ± 4.3 μg/mL, respectively in DPPH antioxidant assay. The antioxidant activity of compound 2 was comparable to the standard antioxidant compound butylated hydroxytoluene (BHT).

Natn.Sci.Foundation Sri Lanka 2015 43 (2): 119-126 
How to Cite: Samanthi, K., Wickramaarachchi, S., Wijeratne, E. and Paranagama, P., 2015. Two new antioxidant active polyketides from Penicillium citrinum, an endolichenic fungus isolated from Parmotreama species in Sri Lanka. Journal of the National Science Foundation of Sri Lanka, 43(2), pp.119–126. DOI: http://doi.org/10.4038/jnsfsr.v43i2.7939
Published on 30 Jun 2015.
Peer Reviewed

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