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Reading: Potent α-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka

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Potent α-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka

Authors:

V Karunaratne,

LK
About V
Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya.
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Vinitha M Thadhani ,

LK
About Vinitha M

Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda.

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Shamsun Nahar Khan,

PK
About Shamsun Nahar

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

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M Iqbal Choudhary

SA
About M Iqbal

Department of Chemistry, School of Sciences. King Saud University, Riyadh-11451, Saudi Arabia.

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Abstract

The discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and other carbohydrate-mediated diseases. This study focused on the lichen Cladonia sp., which yielded three potent α-glucosidase inhibitors, namely zeorin (1), methyl β-orcinolcarboxylate (2) and methylorsellinate (3) with several fold higher inhibitory activities than those of acarbose, an antidiabetic drug used to manage type II diabetes mellitus and the standard, 1-deoxynojirimycin. Atranorin (4) and lobaric acid (5), the other two metabolites isolated from the lichen did not show any α-glucosidase inhibitory potential. All compounds were identified on the basis of one dimentional (1D) and two dimentional (2D) NMR spectral data and with comparison to reported data.

DOI: http://dx.doi.org/10.4038/jnsfsr.v42i1.6684

J.Natn.Sci.Foundation Sri Lanka 2014 42 (1): 95-98

How to Cite: Karunaratne, V., Thadhani, V.M., Khan, S.N. and Choudhary, M.I., 2014. Potent α-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka. Journal of the National Science Foundation of Sri Lanka, 42(1), pp.95–98. DOI: http://doi.org/10.4038/jnsfsr.v42i1.6684
Published on 11 Mar 2014.
Peer Reviewed

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