Short Communications
Potent α-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka
Authors:
V Karunaratne,
LK
About V
Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya.
Vinitha M Thadhani ,
LK
About Vinitha M
Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda.
Shamsun Nahar Khan,
PK
About Shamsun Nahar
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
M Iqbal Choudhary
SA
About M Iqbal
Department of Chemistry, School of Sciences. King Saud University, Riyadh-11451, Saudi Arabia.
Abstract
The discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and other carbohydrate-mediated diseases. This study focused on the lichen Cladonia sp., which yielded three potent α-glucosidase inhibitors, namely zeorin (1), methyl β-orcinolcarboxylate (2) and methylorsellinate (3) with several fold higher inhibitory activities than those of acarbose, an antidiabetic drug used to manage type II diabetes mellitus and the standard, 1-deoxynojirimycin. Atranorin (4) and lobaric acid (5), the other two metabolites isolated from the lichen did not show any α-glucosidase inhibitory potential. All compounds were identified on the basis of one dimentional (1D) and two dimentional (2D) NMR spectral data and with comparison to reported data.
DOI: http://dx.doi.org/10.4038/jnsfsr.v42i1.6684
J.Natn.Sci.Foundation Sri Lanka 2014 42 (1): 95-98
How to Cite:
Karunaratne, V., Thadhani, V.M., Khan, S.N. and Choudhary, M.I., 2014. Potent α-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka. Journal of the National Science Foundation of Sri Lanka, 42(1), pp.95–98. DOI: http://doi.org/10.4038/jnsfsr.v42i1.6684
Published on
11 Mar 2014.
Peer Reviewed
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