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Hepatotoxicity of Schiff bases derived from benzoin salicylaldehyde, aminophenol and 2,4 dinitrophenyl hydrazine

Authors:

M.M. Ali ,

Rajshahi University, BD
About M.M.

Department of Applied Chemistry and Chemical Technology, Rajshahi University, Rajshahi-6205, Bangladesh.

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M. Jesmin

Rajshahi University, BD
About M.
Department of Applied Chemistry and Chemical Technology, Rajshahi University, Rajshahi-6205, Bangladesh.
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Abstract

Hepatotoxicity of three Schiff bases viz. PDH [N-(1- phenyl-2-hydroxy-2-phenylethylidine)-2/,4/dinitrophenylhydrazine],PHP [N-(1-phenyl-2-hydroxy-2-phenylethylidine) 2/ hydroxy phenyl imine] and HHP [N-(2-hydroxy benzylidine)-2/ hydroxy phenyl imine] in both mice with and without Ehrlich Ascites Carcinoma (EAC) was studied. The parameters selected were serum level of the enzymes alanine transaminase, aspartic transaminase, alkaline phosphatase, glucose, blood urea and cholesterol. In mice with no carcinoma there was a modest increase in all the above parameters during the treatment period (10 consecutive days at the dose of 2 mg/kg). After treatment the enhanced values gradually decreased to normal levels. In EAC bearing mice, the toxic effects due to EAC cells in all cases were found to be nullified by treatment of the test compounds. No significant abnormalities in histology of the various organs of the mice were detected due to such treatments.

Keywords: EAC cells, Hepatotoxicity, HHP, histopathology, PDH, PHP.

J.Natn.Sci.Foundation Sri Lanka 2010 38 (2):145-149

Doi: 10.4038/jnsfsr.v38i2.2041

How to Cite: Ali, M.M. and Jesmin, M., 2010. Hepatotoxicity of Schiff bases derived from benzoin salicylaldehyde, aminophenol and 2,4 dinitrophenyl hydrazine. Journal of the National Science Foundation of Sri Lanka, 38(2), pp.145–149. DOI: http://doi.org/10.4038/jnsfsr.v38i2.2041
Published on 30 Jun 2010.
Peer Reviewed

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