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In vitro thrombolytic activity of Sri Lankan black tea, Camellia sinensis (L.) O.Kuntze

Authors:

WD Ratnasooriya ,

Department of Zoology, Faculty of Science, University of Colombo, Colombo 03, LK
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TSP Fernando,

Department of Zoology, Faculty of Science, University of Colombo, Colombo 03, LK
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PP Madubashini

Department of Zoology, Faculty of Science, University of Colombo, Colombo 03, LK
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Abstract

This study examined the thrombolytic potential of black tea [Camellia sinensis (L) O. Kuntze.] in vitro, using Sri Lankan high grown Dust grade No: 1 black tea and goat blood. Different concentrations of tea were made in isotonic saline (2.5, 5, 10 and 20 mg/mL) and added to preclotted blood and the clot lysis activity was determined (in terms of weight and expressed as % of lysis) following 90 minute incubation at 37°C. The results showed that tea induced mild to moderate (121-520%) and significant (p < 0.05) clot lysis activity. This effect was dose-related. However, the clot lytic activity of black tea was markedly lower than streptokinase (0.1 mg/mL). It is concluded that Sri Lankan black tea possesses fast acting mild to moderate thrombolytic activity in vitro when tested on goat blood.

Key words: Black tea, Camellia sinensis (L.) O. Kuntze, clot lysis, Dust grade tea, thrombolytic  

doi:10.4038/jnsfsr.v36i2.151

Journal of the National Science Foundation of Sri Lanka 36 (2) 179-181

How to Cite: Ratnasooriya, W., Fernando, T. and Madubashini, P., 2008. In vitro thrombolytic activity of Sri Lankan black tea, Camellia sinensis (L.) O.Kuntze. Journal of the National Science Foundation of Sri Lanka, 36(2), pp.179–181. DOI: http://doi.org/10.4038/jnsfsr.v36i2.151
Published on 25 Jun 2008.
Peer Reviewed

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